Trying to know God evokes the "higher" fear of God, which is a more inward state, and probes into the Divine essence which gives life to all the worlds.
The relationship to Wisdom is more profound here.
For Wisdom begins with the repudiation of self, a nullification process at the end of which one is equated with "nothing."
And in contemplation of this nothing, Wisdom grows by watching the way all things are born out of the nothing.
For it is by the powers of the Divine word, the breath of the Blessed One, that the world comes into being.
And since all reality in the universe is a product of the spirit of God as expressed by His word, then reality is also nothing in itself, and can be nullified by His spirit.
–Rabbi Adin Steinsaltz
From The Long Shorter Way, Chapter 43, by Rabbi Adin Steinsaltz